K.U. Leuven
Queens University Belfast
APC Microbiome
BenevolentAI
Trinity College Dublin
Icahn School of Medicine, Mount Sinai
Philippe Lemey Prinicipal Investigator, K.U. Leuven
Philippe Lemey's research interests lie in the fields of molecular epidemiology, computational biology and viral evolution. His team studies evolutionary processes that shape viral genetic diversity, spanning from large-scale epidemic processes, such as population growth and spatial dispersal, to small-scale transmission histories and within-host evolutionary processes, including adaptation and recombination. To investigate these different aspects of viral evolution, the team develops and integrates both molecular and computational biology approaches. The team is an important contributor to BEAST ([https://github.com/beast-dev/beast-mcmc](https://github.com/beast-dev/beast-mcmc)), a state-of-the-art Bayesian inference software and has developed phylodynamic models that are widely used for inference of temporal, spatial and adaptation dynamics of virus epidemics.
Gary Hardiman Professor, Queens University Belfast
Prof. Gary Hardiman joined the Faculty of Medicine, Health and Life Sciences and Institute for Global Food Security (IGFS) at Queen’s University Belfast in 2018 as the Chair in Food Systems Biology. His laboratory at QUB works in the field of systems biology the objective of which is the study of biological systems, including genes, RNAs, proteins, metabolites, and cells in a focused manner, and organs, organisms, and populations in a broader context. Current areas of research focus are studying the effects of microplastics on marine and human health; prostate cancer in the context of racial differences and nutritional deficiency; examining the impacts of long-term space travel – specifically the effects of nutrition, torpor, space radiation and microgravity on hepatic and intestinal biology; developing a rat model of opioid abuse; optimizing toolkits for better integration of Omics data sets into genotype-phenotype predictions; and computational analysis to interpret the development of metabolic diseases mediated by non-coding RNAs. Hardiman is co-founder and CTO of the Northern Ireland based precision medicine company Altomics Datamation Ltd. Before moving to Belfast, Hardiman spent his academic career in California and South Carolina, USA. Most recently Hardiman was Scientific Director of the Center for Genomics Medicine Bioinformatics and a full professor in the Departments of Medicine and Public Health Sciences at The Medical University of South Carolina. He was also Head, Laboratory for Marine Systems Biology, Hollings Marine Laboratory, an Adjunct Professor & Visiting Scholar, Grice Marine Laboratory, College of Charleston. He held faculty appointments at the Bioinformatics & Medical Informatics Research Center (BMIRC) and Computational Science Research Center (CSRC), San Diego State University, San Diego and the Department of Medicine at University of California, San Diego. He was the Founding Director of the UCSD Biomedical Genomics Facility (BIOGEM). He served on the advisory boards of several companies including OnRamp Bioinformatics, San Diego, CA; Axikin, La Jolla, CA; Autogenomics, Carlsbad, CA; Molecular Stamping, Trento, Italy. Before returning to academia in 2000, he worked in the biotech industry as a Senior Scientist, at Axys Pharmaceuticals (Quest Diagnostics) in Cambridge, MA; La Jolla, CA & San Francisco, CA. Hardiman received his BSc. Hons. & Ph.D. degrees in Microbiology/Molecular Biology from the National University of Ireland Galway (NUIG) in 1989 and 1993, respectively. He was a University of California/National University of Ireland Education Abroad Scholar and received graduate training at the University of California, Santa Cruz (1992). He completed two post-doctoral research fellowships at DNAX Research Institute (MERCK), Palo Alto, CA (1993-1998) in genomics and bioinformatics. Hardiman serves on the editorial board of the journals ‘Pharmacogenomics’, ‘Expert Review of Molecular Diagnostics’, ACS ES&T Water, Science of the Total Environment (STOTEN), and the MDPI published journals ‘Genes’ and ‘Biotech’ and is an associate editor of ‘Frontiers in Psychiatry -Psychopharmacology’. He has edited three books on genomics technologies, ‘Microarray Methods and Applications’ published by DNA Press, Inc. (2003), ‘Biochips as Pathways to Drug Discovery’ with Dr. Andrew Carmen, published by CRC Press (2007) and ‘Microarray Innovations - Technology & Experimentation’ (2009). He has collaborated with NASA GeneLab, The Gulf of Mexico Research Initiative (GoMRI) on the Deepwater Horizon incident, and the Lipid Maps Consortium.
The human intestinal tract is host to an extensive population of microorganisms working in concert to play a pivotal role in human health. Almost every aspect of modern lifestyles can impact the gut microbiota; recently diet and fitness have been established as important modulators. Previously, we observed that elite athletes have significantly increased gut microbial diversity compared to non-athlete controls. Functional metagenomic analysis revealed this elevated diversity translated into the athletes’ microbiome being primed for energy harvest as well as muscle and tissue repair. However, a subsequent 8-week exercise intervention study failed to reproduce the same high microbial diversity. This lead us to hypothesize that it’s physical fitness, not exercise, that is pivotal to increased microbial diversity. We propose to mine datasets to identify “fitness” associated microbes and metabolites and investigate their implications for human health.
Orla O'Sullivan Research Fellow, APC Microbiome
Orla O'Sullivan completed her PhD in Bioinformatics in 2004 at University College Cork. She is currently a Senior Research Officer (Computational Biologist) at Teagasc and a Principal Investigator at SFI research centres APC Microbiome Ireland and VistaMilk. Her research focuses on the role of the microbiome in diverse environments and the role of exercise and diet on the human gut microbiome.
Human health and disease
Clare West Senior Scientist, BenevolentAI
Clare West is a computational biologist with experience in structural biology and drug discovery. Her postdoctoral research aimed to harness publicly available data to identify and prioritise tractable drug targets within the mechanisms linking ageing and age-related diseases, in collaboration with UK SPINE, the Centre for Medicines Discovery (CMD) at the University of Oxford, and Open Targets at EMBL-EBI. She has a BSc in Biochemistry (University of Nottingham) and a PhD in Protein Informatics (Department of Statistics, University of Oxford) focussing on template-free protein structure prediction.
Dan Bradley Professor and Head of School of Genetics and Microbiology, Trinity College Dublin
His research interests include detection of signatures of selection in human, bovine, salmon and chicken genomes, Irish human population structure, Y chromosome diversity and Irish medieval genealogies, ancient DNA, origins of livestock as discerned using genetic diversity, genetic basis of disease resistance in West African cattle, haplotype decay and the age of cattle hybrid zones, and detection of recombination in mitochondrial genomes.
Niamh Mullins Assistant Professor, Icahn School of Medicine, Mount Sinai
Niamh Mullins is Assistant Professor at the Icahn School of Medicine at Mount Sinai. Her research interests lie in psychiatric genomics, particularly in conducting large-scale genetic studies of bipolar disorder and suicidality. She graduated with a PhD from King's College London in 2017, and now works with the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium and is Co-founder of the International Suicide Genetics Consortium.